Detalhe da pesquisa
1.
The SIAH E3 ubiquitin ligases promote Wnt/ß-catenin signaling through mediating Wnt-induced Axin degradation.
Genes Dev
; 31(9): 904-915, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28546513
2.
Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.
Mol Cell
; 58(3): 522-33, 2015 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25891077
3.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Nature
; 485(7397): 195-200, 2012 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22575959
4.
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Proc Natl Acad Sci U S A
; 110(31): 12649-54, 2013 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23847203
5.
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin.
EMBO Rep
; 14(12): 1120-6, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24165923
6.
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Nature
; 461(7264): 614-20, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19759537
7.
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.
Proc Natl Acad Sci U S A
; 107(35): 15473-8, 2010 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-20713706
8.
Multi-Targeting DKK1 and LRP6 Prevents Bone Loss and Improves Fracture Resistance in Multiple Myeloma.
J Bone Miner Res
; 38(6): 814-828, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36987921
9.
Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites.
Nat Commun
; 13(1): 930, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177623
10.
USP7 inhibits Wnt/ß-catenin signaling through promoting stabilization of Axin.
Nat Commun
; 10(1): 4184, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31519875
11.
Dihydropyrimidine dehydrogenase and thymidylate synthase polymorphisms and their association with 5-fluorouracil/leucovorin chemotherapy in colorectal cancer.
Clin Colorectal Cancer
; 3(4): 225-34, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15025795
12.
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
J Med Chem
; 55(3): 1127-36, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22260203
13.
R-Spondin potentiates Wnt/ß-catenin signaling through orphan receptors LGR4 and LGR5.
PLoS One
; 7(7): e40976, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22815884
14.
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Nat Cell Biol
; 13(5): 623-9, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21478859